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Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines.
- Title
- Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines.
- Authors
- Ryu C.K.; Kang H.Y.; Yi Y.J.; Lee C.O.
- Ewha Authors
- 유충규
- SCOPUS Author ID
- 유충규
- Issue Date
- 2000
- Journal Title
- Archives of Pharmacal Research
- ISSN
- 0253-6269
- Citation
- Archives of Pharmacal Research vol. 23, no. 1, pp. 42 - 45
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- 6-Arylamino-7-halo-5,8-quinolinediones (4a-4k, 5a-5b) were tested for in vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones 4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones 4a and 5a with 7-(4-fluorophenyl)amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds 4f and 4i showed inhibitory activities for the CDK4.
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- 약학대학 > 약학과 > Journal papers
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