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Effects of hydroxylated flavonoids on the ethoxyresorufin O-deethylase and benzo(α)pyrene hydroxylase

Title
Effects of hydroxylated flavonoids on the ethoxyresorufin O-deethylase and benzo(α)pyrene hydroxylase
Authors
Han S.H.Sheen Y.Y.
Ewha Authors
신윤용
SCOPUS Author ID
신윤용scopus
Issue Date
1996
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
Archives of Pharmacal Research vol. 19, no. 6, pp. 514 - 519
Indexed
SCIE; SCOPUS; KCI scopus
Document Type
Article
Abstract
In order to understand the mechanism of action of flavonoids on the drug metabolizing enzyme, cytochrome P450IA1, this study was undertaken to examine the effect of chrysin, morin, myricetin and aminopyrine on the activities of ethoxyresorufin O-deethylase and benzo(α) pyrene hydroxylase in the liver. In the isolated perfused rat liver that was pretreated with 3-methylcholanthrene (3MC), chrysin, morin, myricetin and aminopyrine inhibited the activity of ethoxyresorufin O-deethylase with concentration dependent manner. The isolated liver perfusion with chrysin, morin, myricetin and aminopyrine showed inhibition on the induction of ethoxyresorufin O- deethylase by 3MC. And also, in mouse liver hepa I cells, 3MC-stimulated the benzo(α)pyrene hydroxylase activity which was inhibited by chrysin, morin, myricetin and aminopyrine. These results strongly suggested that hydoxylated flavonoids interfered not only the induction of cytochrome P450IA1 enzymes by 3MC but also the interaction of substrates and enzyme.
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약학대학 > 약학과 > Journal papers
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