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ChimerDB--a knowledgebase for fusion sequences.

Title
ChimerDB--a knowledgebase for fusion sequences.
Authors
Kim N.Kim P.Nam S.Shin S.Lee S.
Ewha Authors
이상혁
SCOPUS Author ID
이상혁scopus
Issue Date
2006
Journal Title
Nucleic acids research.
ISSN
1362-4962JCR Link
Citation
Nucleic acids research. vol. 34, no. Database issue, pp. D21 - 24
Indexed
SCI; SCIE; SCOPUS scopus
Document Type
Article
Abstract
Chromosome translocation and gene fusion are frequent events in the human genome and are often the cause of many types of tumor. ChimerDB is the database of fusion sequences encompassing bioinformatics analysis of mRNA and expressed sequence tag (EST) sequences in the GenBank, manual collection of literature data and integration with other known database such as OMIM. Our bioinformatics analysis identifies the fusion transcripts that have non-overlapping alignments at multiple genomic loci. Fusion events at exon-exon borders are selected to filter out the cloning artifacts in cDNA library preparation. The result is classified into two groups--genuine chromosome translocation and fusion between neighboring genes owing to intergenic splicing. We also integrated manually collected literature and OMIM data for chromosome translocation as an aid to assess the validity of each fusion event. The database is available at http://genome.ewha.ac.kr/ChimerDB/ for human, mouse and rat genomes.
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자연과학대학 > 생명과학전공 > Journal papers
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