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The effect of bacterial endotoxin on the synthesis of interleukin-lβ and prostaglandin e2 by dispersed cells from human decidua
- Title
- The effect of bacterial endotoxin on the synthesis of interleukin-lβ and prostaglandin e2 by dispersed cells from human decidua
- Authors
- Kim Y.J.; Ahn J.J.; Woo B.H.
- Ewha Authors
- 안정자; 우복희; 김영주
- SCOPUS Author ID
- 안정자; 우복희; 김영주
- Issue Date
- 1997
- Journal Title
- Acta Diabetologica Latina
- ISSN
- 0001-5563
- Citation
- Acta Diabetologica Latina vol. 176, no. 1 PART II
- Indexed
- SCOPUS
- Document Type
- Article
- Abstract
- OBJECTIVE: The purposes of this study was to determine the effect of bacterial endotoxin on the synthesis of interleukin-1β (IL-1β) and prostaglandin PG E., (PG E2) hy dispersed cells from human decidua, and to determine the inhibitory effect of anti-IL-1β and transforming growth factor-β, (TGF-β,) on the svnthcsis of ll.-lβ and PC; E., bv dispersed cells from human deridua. STUDY DESIGN: Human decidual cells in monolaver culture were treated with endotoxin. IL-lβ, endotoxin plus monoclonal antihuman ll.-lβ, endotoxin plus TGF-β,. The IL-lβ and PG EL, production were measured by E LISA and RIA. RESULTS: I) The PG EL, and IL-lβ synthesis stimulated with bacterial endotoxin bv decidual cells for 24 hours culture significantly increased in com pat isoii with controls. 2) The PG E.. and II.-l βsynthesis stimulated with bacterial endotoxin and anii-IL-lβ significantly decreased in comparison wiih controls. 3) The PG E, synthesis stimulated with bacterial endotoxin and TGF-β2, significantly decreased in comparison wilh controls. 4) The IL-lβ synthesis stimulated with bacterial endotoxin and TGF-β, significantly increased in comparison with controls. CONCLUSION: Bacterial endotoxin may induce the formation PG E2, through IL-lβ and endotoxin induced preterm labor mav be inhibited ami-IL-lβ and TGF-β2.
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- 의과대학 > 의학과 > Journal papers
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