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Complexation of NADH analogues with β-cyclodextrin: Inhibitory effects of β-cyclodextrin against hydration and copper(II) and hexacyanoferrate(3-) oxidation of 1,4-dihydronicotinamides

Title
Complexation of NADH analogues with β-cyclodextrin: Inhibitory effects of β-cyclodextrin against hydration and copper(II) and hexacyanoferrate(3-) oxidation of 1,4-dihydronicotinamides
Authors
Park J.W.Cha S.Y.Park K.K.
Ewha Authors
박준우
SCOPUS Author ID
박준우scopusscopus
Issue Date
1991
Journal Title
Journal of the Chemical Society, Perkin Transactions 2
ISSN
1472-779XJCR Link
Citation
Journal of the Chemical Society, Perkin Transactions 2, no. 10, pp. 1613 - 1617
Indexed
SCOPUS scopus
Document Type
Article
Abstract
Fluorescent properties and reaction kinetics of the coenzyme NADH analogues 1 (Y),3(X)-disubstituted-1,4-dihydropyridines (Y = benzyl or para-substituted phenyl; X = CONH2, CSNH2, CO2Me, Ac) have been investigated in the presence of β-cyclodextrin (β-CD). From fluorescence measurements, it is concluded that the NADH analogues form 1:1 inclusion complexes with β-CD. The association constant varies sensitively with the nature of the substituents. The proton-catalysed hydration, copper(II) and hexacyanoferrate(3-) ion oxidation reactions of the NADH analogues are retarded by the presence of β-CD. The protective effects of β-CD against the reactions of NADH analogues are attributed to the inaccessibility of the reacting ions to the NADH analogue molecules included in the β-CD cavity, and destabilization of the reaction intermediates or transition states of the rate-determining steps.
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자연과학대학 > 화학·나노과학전공 > Journal papers
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