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Complexation of NADH analogues with β-cyclodextrin: Inhibitory effects of β-cyclodextrin against hydration and copper(II) and hexacyanoferrate(3-) oxidation of 1,4-dihydronicotinamides
- Title
- Complexation of NADH analogues with β-cyclodextrin: Inhibitory effects of β-cyclodextrin against hydration and copper(II) and hexacyanoferrate(3-) oxidation of 1,4-dihydronicotinamides
- Authors
- Park J.W.; Cha S.Y.; Park K.K.
- Ewha Authors
- 박준우
- SCOPUS Author ID
- 박준우
- Issue Date
- 1991
- Journal Title
- Journal of the Chemical Society, Perkin Transactions 2
- ISSN
- 1472-779X
- Citation
- Journal of the Chemical Society, Perkin Transactions 2, no. 10, pp. 1613 - 1617
- Indexed
- SCOPUS
- Document Type
- Article
- Abstract
- Fluorescent properties and reaction kinetics of the coenzyme NADH analogues 1 (Y),3(X)-disubstituted-1,4-dihydropyridines (Y = benzyl or para-substituted phenyl; X = CONH2, CSNH2, CO2Me, Ac) have been investigated in the presence of β-cyclodextrin (β-CD). From fluorescence measurements, it is concluded that the NADH analogues form 1:1 inclusion complexes with β-CD. The association constant varies sensitively with the nature of the substituents. The proton-catalysed hydration, copper(II) and hexacyanoferrate(3-) ion oxidation reactions of the NADH analogues are retarded by the presence of β-CD. The protective effects of β-CD against the reactions of NADH analogues are attributed to the inaccessibility of the reacting ions to the NADH analogue molecules included in the β-CD cavity, and destabilization of the reaction intermediates or transition states of the rate-determining steps.
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- 자연과학대학 > 화학·나노과학전공 > Journal papers
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