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D-4′-thioadenosine derivatives as highly potent and selective agonists at the human A3 adenosine receptor

Title
D-4′-thioadenosine derivatives as highly potent and selective agonists at the human A3 adenosine receptor
Authors
Lee H.W.Shin D.H.Jeong J.Y.Kim H.O.Chun M.W.Melman N.Gao Z.-G.Jacobson K.A.Jeong L.S.
Ewha Authors
정낙신
Issue Date
2005
Journal Title
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770JCR Link
Citation
Nucleosides, Nucleotides and Nucleic Acids vol. 24, no. 41401, pp. 607 - 609
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Conference Paper
Abstract
4′-Thionucleoside derivatives as potent and selective A3 adenosine receptor agonists were synthesized, starting from D-gulono-γ- lactone via D-thioribosyl acetate as a key intermediate, among which the 2· chloro-N6-methyladenosine-5′-methyluronamide showed the most potent and selective binding affinity (Ki = 0.28 ± 0.09 nM) at the human A3 adenosine receptor. Copyright © Taylor & Francis, Inc.
DOI
10.1081/NCN-200061827
Appears in Collections:
약학대학 > 약학과 > Journal papers
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