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Stereoselective synthesis of conformationally rigid apio carbanucleosides as potential antiviral agents

Title
Stereoselective synthesis of conformationally rigid apio carbanucleosides as potential antiviral agents
Authors
Moon H.R.Kim K.R.Kim B.T.Hwang K.J.Chun M.W.Jeong L.S.
Ewha Authors
정낙신
Issue Date
2005
Journal Title
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770JCR Link
Citation
Nucleosides, Nucleotides and Nucleic Acids vol. 24, no. 41401, pp. 709 - 711
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Conference Paper
Abstract
Apio north-methanocarbocyclic nucleosides 1-3 with bicyclo[3.1.0]hexane template were first synthesized. Introduction of hydroxymethyl substituent was efficiently and stereoselectively accomplished by aldol and retro-aldol reaction and fixed conformation was achieved from a modified Simmons-Smith cyclopropanation on a cyclopentane ring. Copyright © Taylor & Francis, Inc.
DOI
10.1081/NCN-200060292
Appears in Collections:
약학대학 > 약학과 > Journal papers
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