Synthesis of 3′-ureidoadenosine analogues and their binding affinity to the A3 adenosine receptor

Abstract

Novel 3′-ureidoadenosine analogues were synthesized from 1,2:5,6-di-0-isopropylidene-D-glucose in order to lead to stronger hydrogen bonding at the A3 adenosine receptor than the corresponding 3-aminoadenosine derivatives. However, all synthesized 3′-ureidoadenosine analogues have lost their binding affinities to the all subtypes of adenosine receptors, indicating that bulky 3′-urea moiety led to conformational distortion. Copyright © Taylor & Francis, Inc.