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약학대학
약학과
Journal papers
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Alteration of collapsin response mediator protein-2 expression in focal ischemic rat brain
Title
Alteration of collapsin response mediator protein-2 expression in focal ischemic rat brain
Authors
Chung M.-A.
;
Lee J.-E.
;
Lee J.-Y.
;
Ko M.-J.
;
Lee S.-T.
;
Kim H.-J.
Ewha Authors
김화정
SCOPUS Author ID
김화정
Issue Date
2005
Journal Title
NeuroReport
ISSN
0959-4965
Citation
NeuroReport vol. 16, no. 15, pp. 1647 - 1653
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
Collapsin response mediator protein-2 is highly expressed in the adult brain and it has been speculated to play roles in nervous system diseases. Studies determined for the first time whether collapsin response mediator protein-2 expression is altered in brain ischemia. We observed ischemia-modulated expression of different-sized collapsin response mediator protein-2. As the ischemic duration increased, the expression level of a known major 62 kDa collapsin response mediator protein-2 was decreased, whereas the expression of a newly-detected 58 kDa collapsin response mediator protein-2 was clearly increased in middle carotid artery-occluded rat brain tissues. Analysis of the two collapsin response mediator protein-2 bands revealed that the novel 58 kDa collapsin response mediator protein-2 observed in middle carotid artery-occluded rat brain tissues was a cleavage form; the predicted cleavage site is located at the carboxy-terminal of the collapsin response mediator protein-2. These data suggest that collapsin response mediator protein-2 is an important candidate controlling ischemic stroke. © 2005 Lippincott Williams & Wilkins.
DOI
10.1097/01.wnr.0000176520.49841.e6
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