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A direct role for dual oxidase in Drosophila gut immunity
- Title
- A direct role for dual oxidase in Drosophila gut immunity
- Authors
- Ha E.-M.; Oh C.-T.; Bae Y.S.; Lee W.-J.
- Ewha Authors
- 배윤수; 이원재
- SCOPUS Author ID
- 배윤수; 이원재
- Issue Date
- 2005
- Journal Title
- Science
- ISSN
- 0036-8075
- Citation
- Science vol. 310, no. 5749, pp. 847 - 850
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Because the mucosal epithelia are in constant contact with large numbers of microorganisms, these surfaces must be armed with efficient microbial control systems. Here, we show that the Drosophila nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme, dual oxidase (dDuox), is indispensable for gut antimicrobial activities. Adult flies in which dDuox expression is silenced showed a marked increase in mortality rate even after a minor infection through ingestion of microbe-contaminated food. This could be restored by the specific reintroduction of dDuox, demonstrating that this oxidase generates a unique epithelial oxidative burst that limits microbial proliferation in the gut. Thus, oxidant-mediated antimicrobial responses are not restricted to the phagocytes, but rather are used more broadly, including in mucosal barrier epithelia.
- DOI
- 10.1126/science.1117311
- Appears in Collections:
- 자연과학대학 > 생명과학전공 > Journal papers
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