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자연과학대학
생명과학전공
Journal papers
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Rac1 GTPase regulates osteoclast differentiation through TRANCE-induced NF-κB activation
Title
Rac1 GTPase regulates osteoclast differentiation through TRANCE-induced NF-κB activation
Authors
Lee N.K.
;
Choi H.K.
;
Kim D.-K.
;
Lee S.Y.
Ewha Authors
이수영
SCOPUS Author ID
이수영
Issue Date
2006
Journal Title
Molecular and Cellular Biochemistry
ISSN
0300-8177
Citation
Molecular and Cellular Biochemistry vol. 281, no. 1-2, pp. 55 - 61
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
Signaling by tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE) is essential for the differentiation of monocytes/ macrophages into osteoclasts. We show here that TRANCE selectively activates Rac1, but not Rac2 in osteoclast precursors. Expression of a dominant interfering mutant of TNF receptor-associated factor (TRAF)6 blocks TRANCE-mediated Rac1 activation, indicating that Rac1 lies downstream of TRAF6. Osteoclast precursors expressing a dominant negative Rac1N17 are defective in TRANCE-induced IKK activation and IκBα degradation resulting in inhibition of NFκB-dependent reporter gene activity. In addition, Rac1 acts upstream of TAK1 to induce NF-κB activation and is required for the normal differentiation of osteoclast precursors. Thus, Rac1 may represent a key regulator for differentiation of osteoclasts through the activation of NF-κB. © Springer Science + Business Media, Inc. 2006.
DOI
10.1007/s11010-006-0333-y
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