Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2018-05-30T08:14:20Z | - |
dc.date.available | 2018-05-30T08:14:20Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0378-4274 | * |
dc.identifier.other | OAK-3048 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243607 | - |
dc.description.abstract | The possible effects of sodium selenite on mature osteoclasts were investigated. Incubation of osteoclast-like cells differentiated from RAW 264.7 cells with sodium selenite induced apoptosis as revealed by morphological changes, internucleosomal DNA fragmentation, and activation of caspase-3. Selenite also induced generation of the superoxide anion and reduced the number of free thiol groups in the osteoclast-like cells, suggestive of a shift to a more oxidizing intracellular environment. In addition, selenite induced protein aggregation by thiol cross-linking, loss of the mitochondrial membrane potential, and cytochrome c release in mitochondria isolated from the osteoclast-like cells. Finally, selenite-induced DNA fragmentation in osteoclasts was inhibited both by cyclosporin A, a blocker of the mitochondrial permeability transition pore, and by DEVD-CHO, a cell-permeable inhibitor of caspase-3. These results thus suggest that selenite induces apoptosis mediated by the mitochondrial pathway in mature osteoclasts. © 2005 Elsevier Ireland Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Selenite-induced apoptosis of osteoclasts mediated by the mitochondrial pathway | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 160 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 143 | * |
dc.relation.lastpage | 150 | * |
dc.relation.journaltitle | Toxicology Letters | * |
dc.identifier.doi | 10.1016/j.toxlet.2005.06.019 | * |
dc.identifier.wosid | WOS:000233764400007 | * |
dc.identifier.scopusid | 2-s2.0-27644570063 | * |
dc.author.google | Chung Y.W. | * |
dc.author.google | Kim T.S. | * |
dc.author.google | Lee S.Y. | * |
dc.author.google | Lee S.H. | * |
dc.author.google | Choi Y. | * |
dc.author.google | Kim N. | * |
dc.author.google | Min B.-M. | * |
dc.author.google | Jeong D.-W. | * |
dc.author.google | Kim I.Y. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |