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dc.contributor.author김춘미-
dc.contributor.author박혜영-
dc.contributor.author김화정-
dc.contributor.author이상국-
dc.contributor.author서은경-
dc.date.accessioned2018-05-30T08:14:19Z-
dc.date.available2018-05-30T08:14:19Z-
dc.date.issued2005-
dc.identifier.issn0014-2999-
dc.identifier.otherOAK-3069-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/243595-
dc.description.abstractIn our previous study, a synthetic benz[f]indole-4,9-dione analog, 2-amino-3-ethoxycarbonyl-N-methylbenz[f]indole-4,9-dione (SME-6), exhibited a potential anti-tumor activity. We, in this study, further explored the anti-metastatic and anti-invasive effect of SME-6 by determining the regulation of matrix metalloproteinases (MMPs). MMPs, zinc-dependent proteolytic enzymes, play a pivotal role in tumor metastasis by cleavage of extracellular matrix as well as non-matrix substrates. On this line, we examined the influence of SME-6 on the expressions of MMP-2, -9, membrane type 1-MMP (MT1-MMP), tissue inhibitor of metalloproteinases (TIMP-1, -2), and in vitro invasiveness of human fibrosarcoma cells. Dose-dependent suppressions of MMPs and TIMP-2 mRNA levels were observed in SME-6-treated HT1080 human fibrosarcoma cells detected by reverse transcriptase-polymerase chain reaction. TIMP-1 mRNA level, however, was induced in a dose-dependent manner. Gelatin zymographic analysis also exhibited a significant down-regulation of MMP-2 and -9 expression in HT1080 cells treated with SME-6 compared to controls. Furthermore, SME-6 inhibited the invasion, motility, and migration of tumor cells. Taken together, these data provide a possible role of SME-6 as a potential antitumor agent with the markedly inhibition of the metastatic and invasive capacity of malignant cells. © 2005 Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.titleInhibitory effects of a benz[f]indole-4,9-dione analog on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells-
dc.typeArticle-
dc.relation.issue41277-
dc.relation.volume527-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage31-
dc.relation.lastpage36-
dc.relation.journaltitleEuropean Journal of Pharmacology-
dc.identifier.doi10.1016/j.ejphar.2005.10.009-
dc.identifier.wosidWOS:000234029900003-
dc.identifier.scopusid2-s2.0-28544436746-
dc.author.googlePark H.J.-
dc.author.googleLee H.-J.-
dc.author.googleMin H.-Y.-
dc.author.googleChung H.-J.-
dc.author.googleSuh M.E.-
dc.author.googlePark-Choo H.-Y.-
dc.author.googleKim C.-
dc.author.googleKim H.J.-
dc.author.googleSeo E.-K.-
dc.author.googleLee S.K.-
dc.contributor.scopusid김춘미(7409876240)-
dc.contributor.scopusid박혜영(34972649500)-
dc.contributor.scopusid김화정(56670336100)-
dc.contributor.scopusid서은경(7005953758)-
dc.date.modifydate20190901081003-
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약학대학 > 약학과 > Journal papers
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