Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김춘미 | * |
dc.contributor.author | 박혜영 | * |
dc.contributor.author | 김화정 | * |
dc.contributor.author | 이상국 | * |
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2018-05-30T08:14:19Z | - |
dc.date.available | 2018-05-30T08:14:19Z | - |
dc.date.issued | 2005 | * |
dc.identifier.issn | 0014-2999 | * |
dc.identifier.other | OAK-3069 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243595 | - |
dc.description.abstract | In our previous study, a synthetic benz[f]indole-4,9-dione analog, 2-amino-3-ethoxycarbonyl-N-methylbenz[f]indole-4,9-dione (SME-6), exhibited a potential anti-tumor activity. We, in this study, further explored the anti-metastatic and anti-invasive effect of SME-6 by determining the regulation of matrix metalloproteinases (MMPs). MMPs, zinc-dependent proteolytic enzymes, play a pivotal role in tumor metastasis by cleavage of extracellular matrix as well as non-matrix substrates. On this line, we examined the influence of SME-6 on the expressions of MMP-2, -9, membrane type 1-MMP (MT1-MMP), tissue inhibitor of metalloproteinases (TIMP-1, -2), and in vitro invasiveness of human fibrosarcoma cells. Dose-dependent suppressions of MMPs and TIMP-2 mRNA levels were observed in SME-6-treated HT1080 human fibrosarcoma cells detected by reverse transcriptase-polymerase chain reaction. TIMP-1 mRNA level, however, was induced in a dose-dependent manner. Gelatin zymographic analysis also exhibited a significant down-regulation of MMP-2 and -9 expression in HT1080 cells treated with SME-6 compared to controls. Furthermore, SME-6 inhibited the invasion, motility, and migration of tumor cells. Taken together, these data provide a possible role of SME-6 as a potential antitumor agent with the markedly inhibition of the metastatic and invasive capacity of malignant cells. © 2005 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.title | Inhibitory effects of a benz[f]indole-4,9-dione analog on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells | * |
dc.type | Article | * |
dc.relation.issue | 41277 | * |
dc.relation.volume | 527 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 31 | * |
dc.relation.lastpage | 36 | * |
dc.relation.journaltitle | European Journal of Pharmacology | * |
dc.identifier.doi | 10.1016/j.ejphar.2005.10.009 | * |
dc.identifier.wosid | WOS:000234029900003 | * |
dc.identifier.scopusid | 2-s2.0-28544436746 | * |
dc.author.google | Park H.J. | * |
dc.author.google | Lee H.-J. | * |
dc.author.google | Min H.-Y. | * |
dc.author.google | Chung H.-J. | * |
dc.author.google | Suh M.E. | * |
dc.author.google | Park-Choo H.-Y. | * |
dc.author.google | Kim C. | * |
dc.author.google | Kim H.J. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Lee S.K. | * |
dc.contributor.scopusid | 김춘미(7409876240) | * |
dc.contributor.scopusid | 박혜영(34972649500;57200273796) | * |
dc.contributor.scopusid | 김화정(56670336100) | * |
dc.contributor.scopusid | 이상국(36067620500) | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118124308 | * |