Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승진 | - |
dc.date.accessioned | 2018-05-30T08:14:17Z | - |
dc.date.available | 2018-05-30T08:14:17Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0885-4513 | - |
dc.identifier.other | OAK-3101 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243584 | - |
dc.description.abstract | BMP-2 (bone morphogenetic protein-2) has been used in promoting bone formation and, in combination with various delivery carriers, in bone regeneration or bone tissue-engineering practice. In the present study, BMP-2 was immobilized directly on a GBR (guided bone-regenerative) membrane surface made of chitosan nanofibres, providing a bioactive surface that can enhance bone-regeneration capacity. The BMP-2-conjugated membrane surface retained bioactivity for up to 4 weeks of incubation, as well as holding over 50% of the initial BMP-2 attached. The BMP-2-conjugated surface increased osteoblastic cell attachment in accordance with the amount of BMP-2 conjugated. In addition, the BMP-2-conjugated chitosan membrane significantly promoted cell proliferation, alkaline phosphatase activity, as well as calcium deposition when compared with BMP-2-adsorbed membrane, indicating a stable localization of BMP-2 at the surface of the chitosan membrane. Taking these findings together, the conjugation of BMP-2 on a chitosan nanofibrous membrane would seen to be applicable for inducing significant and localized bone formation in future GBR procedures. © 2006 Portland Press Ltd. | - |
dc.language | English | - |
dc.title | Immobilization of bone morphogenetic protein-2 on a nanofibrous chitosan membrane for enhanced guided bone regeneration | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 43 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 17 | - |
dc.relation.lastpage | 24 | - |
dc.relation.journaltitle | Biotechnology and Applied Biochemistry | - |
dc.identifier.doi | 10.1042/BA20050075 | - |
dc.identifier.wosid | WOS:000234412700003 | - |
dc.identifier.scopusid | 2-s2.0-30344442151 | - |
dc.author.google | Park Y.J. | - |
dc.author.google | Kim K.H. | - |
dc.author.google | Lee J.Y. | - |
dc.author.google | Ku Y. | - |
dc.author.google | Lee S.J. | - |
dc.author.google | Min B.M. | - |
dc.author.google | Chung C.P. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.date.modifydate | 20230118105419 | - |