Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배윤수 | * |
dc.date.accessioned | 2018-05-30T08:14:17Z | - |
dc.date.available | 2018-05-30T08:14:17Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-3103 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243583 | - |
dc.description.abstract | It is well established that growth-factor-induced reactive oxygen species (ROS) act as second messengers in cell signaling. We have previously reported that βPix, a guanine nucleotide exchange factor for Rac, interacts with NADPH oxidase 1 (Nox1) leading to EGF-induced ROS generation. Here, we report the identification of the domains of Nox1 and βPix responsible for the interaction between the two proteins. GST pull-down assays show that the PH domain of βPix binds to the FAD-binding region of Nox1. We also show that overexpression of the PH domain of βPix results in inhibition of superoxide anion generation in response to EGF. Additionally, NADPH oxidase Organizer 1 (NoxO1) is shown to interact with the NADPH-binding region of Nox1. These results suggest that the formation of the complex consisting of Nox1, βPix, and NoxO1 is likely to be a critical step in EGF-induced ROS generation. © 2005 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | Molecular interaction of NADPH oxidase 1 with βpix and Nox Organizer 1 | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 339 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 985 | * |
dc.relation.lastpage | 990 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/j.bbrc.2005.11.108 | * |
dc.identifier.wosid | WOS:000234439200037 | * |
dc.identifier.scopusid | 2-s2.0-28844479984 | * |
dc.author.google | Park H.S. | * |
dc.author.google | Park D. | * |
dc.author.google | Bae Y.S. | * |
dc.contributor.scopusid | 배윤수(15031067200) | * |
dc.date.modifydate | 20240415133331 | * |