Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오구택 | * |
dc.date.accessioned | 2018-05-30T08:14:15Z | - |
dc.date.available | 2018-05-30T08:14:15Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-3119 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243573 | - |
dc.description.abstract | AMP-activated protein kinase (AMPK) activation increases fatty acid oxidation in skeletal muscle by decreasing malonyl CoA concentrations. However, this may not explain the long-term effects of AMPK activation. Here we show that AMPK activation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) increases mRNA expression of PPARα target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle, and that inhibition of PPARα and PGC-1 by siRNAs prevents AICAR-stimulated increase in fatty acid oxidation. These data suggest that a novel transcriptional regulatory mechanism involving PPARα and PGC-1 exists that is responsible for long-term stimulation of fatty acid oxidation in skeletal muscle by AICAR. © 2005 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARα and PGC-1 | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 340 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 291 | * |
dc.relation.lastpage | 295 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/j.bbrc.2005.12.011 | * |
dc.identifier.wosid | WOS:000234640600043 | * |
dc.identifier.scopusid | 2-s2.0-29244436681 | * |
dc.author.google | Lee W.J. | * |
dc.author.google | Kim M. | * |
dc.author.google | Park H.-S. | * |
dc.author.google | Kim H.S. | * |
dc.author.google | Jeon M.J. | * |
dc.author.google | Oh K.S. | * |
dc.author.google | Koh E.H. | * |
dc.author.google | Won J.C. | * |
dc.author.google | Kim M.-S. | * |
dc.author.google | Oh G.T. | * |
dc.author.google | Yoon M. | * |
dc.author.google | Lee K.-U. | * |
dc.author.google | Park J.-Y. | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.date.modifydate | 20240123094756 | * |