Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오억수 | - |
dc.date.accessioned | 2018-05-30T08:14:07Z | - |
dc.date.available | 2018-05-30T08:14:07Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0969-9961 | - |
dc.identifier.other | OAK-3212 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243518 | - |
dc.description.abstract | The aim of this study was to investigate the role of microglia in radiation-induced astrocyte gliosis. We found that a single dose of 15 Gy radiation to a whole rat brain increased immunostaining of glial fibrillary acidic protein in astrocytes 6 h later, and even more so 24 h later, indicating the initiation of gliosis. While irradiation of cultured rat astrocytes had little effect, irradiation of microglia-astrocyte mixed-cultures displayed altered astrocyte phenotype into more processed, which is another characteristic of gliosis. Experiments using microglia-conditioned media indicated this astrocyte change was due to factors released from irradiated microglia. Irradiation of cultured mouse microglial cells induced a dose-dependent increase in mRNA levels for cyclooxygenase-2 (COX-2), interleukin (IL)-1β, IL-6, IL-18, tumor necrosis factor-α and interferon-γ-inducible protein-10, which are usually associated with microglia activation. Consistent with these findings, irradiation of microglia activated NF-κB, a transcription factor that regulates microglial activation. Addition of prostaglandin E 2 (PGE 2: a metabolic product of the COX-2 enzyme) to primary cultured rat astrocytes resulted in phenotypic changes similar to those observed in mixed-culture experiments. Therefore, it appears that PGE 2 released from irradiated microglia is a key mediator of irradiation-induced gliosis or astrocyte phenotype change. These data suggest that radiation-induced microglial activation and resultant production of PGE 2 seems to be associated with an underlying cause of inflammatory complications associated with radiation therapy for malignant gliomas. © 2005 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.title | Ionizing radiation induces astrocyte gliosis through microglia activation | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 21 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 457 | - |
dc.relation.lastpage | 467 | - |
dc.relation.journaltitle | Neurobiology of Disease | - |
dc.identifier.doi | 10.1016/j.nbd.2005.08.006 | - |
dc.identifier.wosid | WOS:000235899100001 | - |
dc.identifier.scopusid | 2-s2.0-33244488276 | - |
dc.author.google | Hwang S.-Y. | - |
dc.author.google | Jung J.-S. | - |
dc.author.google | Kim T.-H. | - |
dc.author.google | Lim S.-J. | - |
dc.author.google | Oh E.-S. | - |
dc.author.google | Kim J.-Y. | - |
dc.author.google | Ji K.-A. | - |
dc.author.google | Joe E.-H. | - |
dc.author.google | Cho K.-H. | - |
dc.author.google | Han I.-O. | - |
dc.contributor.scopusid | 오억수(7101967153) | - |
dc.date.modifydate | 20190901081003 | - |