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Prevalence of plasmid-mediated AmpC β-lactamases in Escherichia coli and Klebsiella pneumoniae in Korea
- Title
- Prevalence of plasmid-mediated AmpC β-lactamases in Escherichia coli and Klebsiella pneumoniae in Korea
- Authors
- Lee K.; Lee M.; Shin J.H.; Lee M.H.; Kang S.H.; Park A.J.; Yong D.; Chong Y.
- Ewha Authors
- 이미애
- SCOPUS Author ID
- 이미애
- Issue Date
- 2006
- Journal Title
- Microbial Drug Resistance
- ISSN
- 1076-6294
- Citation
- Microbial Drug Resistance vol. 12, no. 1, pp. 44 - 49
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Cefoxitin-resistant Escherichia coli and Klebsiella pneumoniae are relatively prevalent in Korea, suggesting dissemination of plasmid-mediated AmpC β-lactamases. In this study, 238 isolates of cefositin-resistant E. coli and K, pneumoniae (not including subspecies ozaenae and rhinoscleromatis) were collected in 2003 from 16 Korean hospitals. The prevalence of plasmid-mediated AmpC β-lactamases was determined by PCR. The AmpC gene alleles detected in E. coli and K. pneumoniae were blaDHA-1, 10 (8.6%) and 93 (76.2%); blaCMY-1-like, 14 (12.1%) and 2 (1.6%); and blaCMY-2-like, 38 (32.7%) and 1 (0.8%) isolates, respectively. The genes identified were blaDHA-1, blaCMY10-like, and blaCMY-2-like, and a new variant, blaCMY-18. Plasmid-mediated AmpC gene allele-positive isolates were present both in large city and in small province hospitals, as well as in isolates from outpatients. The proportions of plasmid-mediated AmpC gene-positive isolates were similar in both expanded spectrum β-lactamase (ESBL)-producing and -nonproducing isolates. In conclusion, DHA-1, CMY-2-like, and CMY-10-like plasmid-mediated AmpC β-lactamase-producing K. pneumoniae and E. coli isolates are widely disseminated in both large city and small province hospitals. Absence of blaCMY-1 and detection of a novel variant of blaCMY-2, blaCMY-18, indicate continued evolution of the prototype genes. Similar proportions of plasmid-mediated AmpC gene-positive isolates in both ESBL-producing and -nonproducing isolates suggest unhindered future spread of these resistances. © Mary Ann Liebert, Inc.
- DOI
- 10.1089/mdr.2006.12.44
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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