Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신윤용 | * |
dc.contributor.author | 김대기 | * |
dc.date.accessioned | 2018-05-30T08:13:59Z | - |
dc.date.available | 2018-05-30T08:13:59Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0008-5472 | * |
dc.identifier.other | OAK-3339 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243461 | - |
dc.description.abstract | A novel synthetic inhibitor of histone deacetylase (HDAC), 3-(4-dimethylaminophenyl)-N-hydroxy-2-propenamide (IN-2001), was examined for its antitumor activity and for the underlying molecular mechanisms of any such activity. IN-2001 effectively inhibited cellular HDAC activity (IC 50, 5.42 nmol/L) in MCF-7 human breast cancer cells. Based on the Western blot analysis, this HDAC inhibitory effect of IN-2001 was confirmed by an increase in histone H4 acetylation from the IN-2001-treated breast cancer cells. IN-2001 suppressed mammary tumor growth in MMTV/c-Neu transgenic mice and also showed higher apoptotic index and lower lymphatic invasion compared with controls. In human breast cancer cells (MCF-7, T47D, MDA-MB-231, and MDA-MB-468), IN-2001 induced cell cycle arrest at G 2-M phase through up-regulation of p21 WAF1 and p27 KIP1 and eventually caused apoptosis. IN-2001-induced apoptosis was caspase dependent and seems mediated through an increase in Bax/Bcl-2 ratio. Taken together, our data indicate that this novel HDAC inhibitor is a promising therapeutic agent against human breast cancer. ©2006 American Association for Cancer Research. | * |
dc.language | English | * |
dc.title | Potent in vivo anti-breast cancer activity of IN-2001, a novel inhibitor of histone deacetylase, in MMTV/c-Neu Mice | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 66 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 5394 | * |
dc.relation.lastpage | 5402 | * |
dc.relation.journaltitle | Cancer Research | * |
dc.identifier.doi | 10.1158/0008-5472.CAN-05-3835 | * |
dc.identifier.wosid | WOS:000237679900052 | * |
dc.identifier.scopusid | 2-s2.0-33744915538 | * |
dc.author.google | Joung K.E. | * |
dc.author.google | Min K.N. | * |
dc.author.google | An J.Y. | * |
dc.author.google | Kim D.-K. | * |
dc.author.google | Kong G. | * |
dc.author.google | Sheen Y.Y. | * |
dc.contributor.scopusid | 신윤용(6603872711) | * |
dc.contributor.scopusid | 김대기(35083694200) | * |
dc.date.modifydate | 20240118164500 | * |