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Effects of lifestyle modifications on C-reactive protein: contribution of weight loss and improved aerobic capacity
- Title
- Effects of lifestyle modifications on C-reactive protein: contribution of weight loss and improved aerobic capacity
- Authors
- Jae S.Y.; Fernhall B.; Heffernan K.S.; Jeong M.; Chun E.M.; Sung J.; Lee S.H.; Lim Y.J.; Park W.H.
- Ewha Authors
- 천은미
- SCOPUS Author ID
- 천은미
- Issue Date
- 2006
- Journal Title
- Metabolism: Clinical and Experimental
- ISSN
- 0026-0495
- Citation
- Metabolism: Clinical and Experimental vol. 55, no. 6, pp. 825 - 831
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- High-sensitivity C-reactive protein (hs-CRP) is associated with an increased risk of cardiovascular disease and the development of type 2 diabetes mellitus. We analyzed the effects of lifestyle modifications including exercise training on hs-CRP in 47 overweight and obese adults. Subjects were divided into a lifestyle modification group (n = 23) (exercise and diet instruction) and a control group (n = 24) who did not participate in any lifestyle modification. After 3 months, body weight (80.8 ± 11.5 to 73.5 ± 10.7 kg, P < .01), total cholesterol (217 ± 38.4 to 178.0 ± 25.6 mg/dL, P < .01), low-density lipoprotein cholesterol (151.3 ± 34.9 to 116.7 ± 27.8 mg/dL, P < .01), Vo2peak (30.3 ± 5.1 to 37.1 ± 6.9 mL/[kg · min], P < .01), and log hs-CRP (0.75 ± 0.4 to 0.56 ± 0.3 mg/dL, P = .01) were significantly improved in the lifestyle modification group, but there was no significant improvement in the control group. Changes in log hs-CRP were associated with changes in Vo2peak (r = -0.41, P = .004) and changes in weight loss (r = 0.42, P = .004). In stepwise multiple regression analysis, weight loss (P = .034) and improved Vo2peak (P = .039) were independent predictors of the changes in hs-CRP. When grouped into quartiles according to decreasing weight and increasing Vo2peak, levels of changes in log hs-CRP improved across quartiles of weight loss (P < .05) and improved Vo2peak (P < .01). Thus, lifestyle changes including regular exercise training in overweight and obese adults decreased hs-CRP, and this was associated with weight loss and improved Vo2peak. © 2006 Elsevier Inc. All rights reserved.
- DOI
- 10.1016/j.metabol.2006.02.010
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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