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Oxidative stress during peritoneal dialysis: Implications in functional and structural changes in the membrane

Title
Oxidative stress during peritoneal dialysis: Implications in functional and structural changes in the membrane
Authors
Noh H.Kim J.S.Han K.-H.Lee G.T.Song J.S.Chung S.H.Jeon J.S.Ha H.Lee H.B.
Ewha Authors
하헌주한기환
SCOPUS Author ID
하헌주scopus; 한기환scopus
Issue Date
2006
Journal Title
Kidney International
ISSN
0085-2538JCR Link
Citation
Kidney International vol. 69, no. 11, pp. 2022 - 2028
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Progressive peritoneal fibrosis, membrane hyperpermeability, and ultrafiltration failure have been observed in patients on long-term peritoneal dialysis (PD). The present study tested the hypothesis that reactive oxygen species (ROS) generated by conventional PD solution (PDS) mediate functional and structural alterations of peritoneal membrane in vivo. Sprague-Dawley rats were randomized to control, PDS, PDS with an antioxidant, and PDS with an angiotensin II (Ang II) receptor blocker. Commercial PDS containing 3.86% glucose (20-30 ml) with or without N-acetylcystein (NAC) 10 mM or losartan 5 mg/kg was administered intraperitoneally twice a day for 12 weeks. Control rats received sham injection. Rats treated with PDS had significantly lower drain volume and D 4/D 0 glucose, but higher D 4/P 4 creatinine and increased membrane thickness and endothelial NOS (eNOS) expression compared to control rats. Omental transforming growth factor (TGF)-β1, vascular endothelial growth factor (VEGF), collagen I, and heat-shock protein (hsp) 47 expression and lipid peroxide levels and dialysate VEGF and Ang II concentrations were significantly increased in rats treated with PDS compared to control. All of these changes were prevented by both NAC and losartan. In conclusion, the present study demonstrates that ROS generated by conventional PDS are, in large part, responsible for peritoneal fibrosis and membrane hyperpermeability. We suggest that antioxidants or Ang II receptor blockers may allow better preservation of the structural and functional integrity of the peritoneal membrane during long-term PD. © 2006 International Society of Nephrology.
DOI
10.1038/sj.ki.5001506
Appears in Collections:
약학대학 > 약학과 > Journal papers
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