Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2018-05-30T08:13:51Z | - |
dc.date.available | 2018-05-30T08:13:51Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 1350-9047 | * |
dc.identifier.other | OAK-3421 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243406 | - |
dc.description.abstract | This study sought to characterize the reduced glutathione (GSH)/oxidized GSSG ratio during osteoclast differentiation and determine whether changes in the intracellular redox status regulate its differentiation through a RANKL-dependent signaling pathway. A progressive decrease of the GSH/GSSG ratio was observed during osteoclast differentiation, and the phenomenon was dependent on a decrease in total glutathione via downregulation of expression of the γ-glutamylcysteinyl synthetase modifier gene. Glutathione depletion by L-buthionine-(S,R)-sulfoximine (BSO) was found to inhibit osteoclastogenesis by blocking nuclear import of NF-κB and AP-1 in RANKL-propagated signaling and bone pit formation by increasing BSO concentrations in mature osteoclasts. Furthermore, intraperitoneal injection of BSO in mice resulted in an increase in bone density and a decrease of the number of osteoclasts in bone. Conversely, glutathione repletion with either N-acetylcysteine or GSH enhanced osteoclastogenesis. These findings indicate that redox status decreases during osteoclast differentiation and that this modification directly regulates RANKL-induced osteoclastogenesis. © 2006 Nature Publishing Group. All rights reserved. | * |
dc.language | English | * |
dc.title | Regulation of osteoclast differentiation by the redox-dependent modulation of nuclear import of transcription factors | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1138 | * |
dc.relation.lastpage | 1146 | * |
dc.relation.journaltitle | Cell Death and Differentiation | * |
dc.identifier.doi | 10.1038/sj.cdd.4401793 | * |
dc.identifier.wosid | WOS:000238802500011 | * |
dc.identifier.scopusid | 2-s2.0-33745218280 | * |
dc.author.google | Huh Y.-J. | * |
dc.author.google | Kim J.-M. | * |
dc.author.google | Kim H. | * |
dc.author.google | Song H. | * |
dc.author.google | So H. | * |
dc.author.google | Lee S.Y. | * |
dc.author.google | Kwon S.B. | * |
dc.author.google | Kim H.J. | * |
dc.author.google | Kim H.-H. | * |
dc.author.google | Lee S.H. | * |
dc.author.google | Choi Y. | * |
dc.author.google | Chung S.-C. | * |
dc.author.google | Jeong D.-W. | * |
dc.author.google | Min B.-M. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |