Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이공주 | - |
dc.date.accessioned | 2018-05-18T08:15:23Z | - |
dc.date.available | 2018-05-18T08:15:23Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.other | OAK-2513 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243249 | - |
dc.description.abstract | Switching specific patterns of gene repression and activation in response to precise temporal/spatial signals is critical for normal development. Here we report a pathway in which induction of CaMKIIδ triggers an unexpected switch in the function of the HES1 transcription factor from a TLE-dependent repressor to an activator required for neuronal differentiation. These events are based on activation of the poly(ADP-ribose) polymerase1 (PARP-1) sensor component of the groucho/TLE-corepressor complex mediating dismissal of the corepressor complex from HES1-regulated promoters. In parallel, CaMKIIδ mediates a required phosphorylation of HES1 to permit neurogenic gene activation, revealing the ability of a specific signaling pathway to modulate both the derepression and the subsequent coactivator recruitment events required for transcriptional activation of a neurogenic program. The identification of PARP-1 as a regulated promoter-specific exchange factor required for activation of specific neurogenic gene programs is likely to be prototypic of similar molecular mechanisms. | - |
dc.language | English | - |
dc.title | Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIδ-dependent neurogenic gene activation pathway | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 119 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 815 | - |
dc.relation.lastpage | 829 | - |
dc.relation.journaltitle | Cell | - |
dc.identifier.doi | 10.1016/j.cell.2004.11.017 | - |
dc.identifier.wosid | WOS:000225907200012 | - |
dc.identifier.scopusid | 2-s2.0-10944253639 | - |
dc.author.google | Ju B.-G. | - |
dc.author.google | Solum D. | - |
dc.author.google | Song E.J. | - |
dc.author.google | Lee K.-J. | - |
dc.author.google | Rose D.W. | - |
dc.author.google | Glass C.K. | - |
dc.author.google | Rosenfeld M.G. | - |
dc.contributor.scopusid | 이공주(7501497635;57191532162) | - |
dc.date.modifydate | 20230208115507 | - |