Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽혜선 | * |
dc.date.accessioned | 2018-05-18T08:15:14Z | - |
dc.date.available | 2018-05-18T08:15:14Z | - |
dc.date.issued | 2005 | * |
dc.identifier.issn | 1570-0232 | * |
dc.identifier.other | OAK-2629 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243188 | - |
dc.description.abstract | Amosulalol is an antihypertensive drug with selective postsynaptic alpha 1 and non-selective beta blocking effects. A simple solid-phase extraction and high-performance liquid chromatographic (HPLC) method has been developed and validated for the quantitative determination of amosulalol in human plasma. A reversed phase C18 column was used for the separation of amosulalol and ethyl paraben (internal standard) with a mobile phase composed of 0.025 M phosphate buffer (pH 6.0)·acetonitrile (73:27, v/v) at a flow rate of 1.5 mL/min. The ultraviolet detector was operated at the 272 nm wavelength. Intra- and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification of 30 ng/mL. Recovery of amosulalol from human plasma was >95.6%. Amosulalol was stable in human plasma under various storage conditions. This method was used successfully for a pharmacokinetic study in plasma after oral administration of a single 20 mg dose of amosulalol hydrochloride to 16 healthy volunteers. © 2004 Published by Elsevier B.V. | * |
dc.language | English | * |
dc.title | Determination of amosulalol in human plasma using solid-phase extraction combined with liquid chromatography and ultraviolet detection | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 818 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 109 | * |
dc.relation.lastpage | 113 | * |
dc.relation.journaltitle | Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences | * |
dc.identifier.doi | 10.1016/j.jchromb.2004.06.029 | * |
dc.identifier.wosid | WOS:000227629200001 | * |
dc.identifier.scopusid | 2-s2.0-14744290219 | * |
dc.author.google | Gwak H.S. | * |
dc.author.google | Noh E.S. | * |
dc.author.google | Lee N.Y. | * |
dc.author.google | Chun I.K. | * |
dc.date.modifydate | 20240422115307 | * |