Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손연수 | - |
dc.date.accessioned | 2018-05-18T08:14:58Z | - |
dc.date.available | 2018-05-18T08:14:58Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.other | OAK-2824 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243089 | - |
dc.description.abstract | A new amphiphilic poly(organophosphazene) was synthesized by stepwise nucleophilic substitutions with a hydrophilic methoxy poly(ethylene glycol) with an average molecular weight of 350 (MPEG350) and a hydrophobic glycyl-l-glutamate as side groups, and then an antitumor (dach)platinum(II) (dach: trans-(±)-1,2-diaminocyclohexane) moiety was conjugated to the polymer using the dipeptide as a spacer. This polymeric platinum conjugate was found to be accumulated in the tumor tissue to a remarkably greater extent than in the normal tissue (tumor/tissue ratio >4), probably due to the excellent EPR effect and the long circulating properties of the polymer conjugate (t 1/2β = 6.2 h and AUC = 4020 nmol h/ml) compared with carboplatin (t1/2β = 0.42 h and AUC = 120 nmol h/ml). The polymer conjugate also exhibited high in vitro cytotoxicity comparable to cisplatin against several human tumor cells tested. © 2005 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.title | Synthesis, characterization, and tumor selectivity of a polyphosphazene-platinum(II) conjugate | - |
dc.type | Article | - |
dc.relation.issue | 41276 | - |
dc.relation.volume | 105 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 142 | - |
dc.relation.lastpage | 150 | - |
dc.relation.journaltitle | Journal of Controlled Release | - |
dc.identifier.doi | 10.1016/j.jconrel.2005.03.016 | - |
dc.identifier.wosid | WOS:000230576600013 | - |
dc.identifier.scopusid | 2-s2.0-20444427224 | - |
dc.author.google | Song R. | - |
dc.author.google | Yong J.J. | - |
dc.author.google | Ju I.K. | - |
dc.author.google | Jin C. | - |
dc.author.google | Youn S.S. | - |
dc.contributor.scopusid | 손연수(7201971323) | - |
dc.date.modifydate | 20180517114919 | - |