Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김원기 | * |
dc.contributor.author | 김희선 | * |
dc.date.accessioned | 2018-05-18T08:14:51Z | - |
dc.date.available | 2018-05-18T08:14:51Z | - |
dc.date.issued | 2005 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-2904 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243042 | - |
dc.description.abstract | The aberrant expression of matrix metalloproteinase-9 (MMP-9) is implicated in the invasion and angiogenesis process of brain tumor. This study has investigated the effects of curcumin on MMP-9 expression in human astroglioma cell lines. Curcumin significantly inhibited the MMP-9 enzymatic activity and protein expression that was induced by PMA. The inhibitory effect of curcumin on MMP-9 expression correlates with the decreased MMP-9 mRNA level and the suppression of MMP-9 promoter activity. The curcumin-mediated inhibition of MMP-9 gene expression appears to occur via NF-κB and AP-1 because their DNA binding activities were suppressed by curcumin. Furthermore, curcumin strongly repressed the PMA-induced phosphorylation of ERK, JNK, and p38 MAP kinase, which were dependent on the PKC pathway. Therefore, the inhibition of MMP-9 expression by curcumin might have therapeutic potential for controlling the growth and invasiveness of brain tumor. © 2005 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 335 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1017 | * |
dc.relation.lastpage | 1025 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/j.bbrc.2005.07.174 | * |
dc.identifier.wosid | WOS:000231817600005 | * |
dc.identifier.scopusid | 2-s2.0-24044532589 | * |
dc.author.google | Woo M.-S. | * |
dc.author.google | Jung S.-H. | * |
dc.author.google | Kim S.-Y. | * |
dc.author.google | Hyun J.-W. | * |
dc.author.google | Ko K.-H. | * |
dc.author.google | Kim W.-K. | * |
dc.author.google | Kim H.-S. | * |
dc.contributor.scopusid | 김원기(34770946200) | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.date.modifydate | 20240118140922 | * |