Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상국 | * |
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2018-05-02T08:15:48Z | - |
dc.date.available | 2018-05-02T08:15:48Z | - |
dc.date.issued | 2004 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.other | OAK-2101 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242809 | - |
dc.description.abstract | Activity-guided fractionation of the n-hexane and CHCl3-soluble fractions of Sindora sumatrana using a bioassay based on the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production by inducible nitric oxide synthase (iNOS) in murine macrophage RAW 264.7 cells led to the isolation of the known compound, (+)-7β-acetoxy-15,16-epoxy-3,13(16),14- clerodatriene-18-oic acid (2) as an active constituent. In addition, a new trans-clerodane diterpenoid, (+)-2-oxokolavenic acid (1), together with six known compounds, (+)-3,13-clerodadiene-16,15-olide-18-oic acid (3), (+)-7β-acetoxy-3,13-clerodadiene-16,15-olide-18-oic acid (4), (+)-7β-acetoxy-16-hydroxy-3,13-clerodadiene-16,15-olide-18-oic acid (5), β-caryophyllene oxide (6), clovane-2β,9β-diol (7), and caryolane-1,9β-diol (8) were isolated and found to be inactive. The structure of compound 1 was determined using physical and spectroscopic methods such as 1D and 2D-NMR experiments. The known compounds 2-8 were identified by the spectroscopic data and by comparison with the published values. Of eight isolates (1-8), only compound 2 exhibited an iNOS inhibitory activity with IC50 value of 51.6 μM. | * |
dc.language | English | * |
dc.title | Di- and sesqui-terpenoids isolated from the pods of Sindora sumatrana and their potential to inhibit lipopolysaccharide-induced nitric oxide production | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 27 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 291 | * |
dc.relation.lastpage | 294 | * |
dc.relation.journaltitle | Archives of Pharmacal Research | * |
dc.identifier.doi | 10.1007/BF02980062 | * |
dc.identifier.wosid | WOS:000220534200005 | * |
dc.identifier.scopusid | 2-s2.0-7044260755 | * |
dc.author.google | Dae S.J. | * |
dc.author.google | Min H.-Y. | * |
dc.author.google | Jeong Y.-H. | * |
dc.author.google | Sang K.L. | * |
dc.author.google | Seo E.-K. | * |
dc.contributor.scopusid | 이상국(36067620500) | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |