DSpace at EWHA: Synthesis and biological evaluation of novel 2-pyridinyl-[1,2,3]triazoles as inhibitors of transforming growth factor β1 type 1 receptor

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DC Field	Value	Language
dc.contributor.author	김대기	*
dc.date.accessioned	2018-05-02T08:15:42Z	-
dc.date.available	2018-05-02T08:15:42Z	-
dc.date.issued	2004	*
dc.identifier.issn	0960-894X	*
dc.identifier.other	OAK-2160	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/242775	-
dc.description.abstract	A series of 2-pyridinyl-[1,2,3]triazoles have been synthesized and evaluated for their ALK5 inhibitory activity in the luciferase reporter assays. Compound 8d showed significant ALK5 inhibition (SBE-luciferase activity, 25%; p3TP-luciferase activity, 17%) at a concentration of 5μM that is comparable to that of SB-431542 (SBE-luciferase activity, 21%; p3TP-luciferase activity, 12%), but weak p38α MAP kinase inhibition (13%) at a concentration of 10μM that is much lower than that of SB-431542 (54%). © 2004 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.title	Synthesis and biological evaluation of novel 2-pyridinyl-[1,2,3]triazoles as inhibitors of transforming growth factor β1 type 1 receptor	*
dc.type	Article	*
dc.relation.issue	10	*
dc.relation.volume	14	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	2401	*
dc.relation.lastpage	2405	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	*
dc.identifier.doi	10.1016/j.bmcl.2004.03.024	*
dc.identifier.wosid	WOS:000221316000003	*
dc.identifier.scopusid	2-s2.0-1942534588	*
dc.author.google	Kim D.-K.	*
dc.author.google	Kim J.	*
dc.author.google	Park H.-J.	*
dc.contributor.scopusid	김대기(35083694200)	*
dc.date.modifydate	20240118164500	*