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The moleskin gene product is essential for Caudal-mediated constitutive antifungal Drosomycin gene expression in Drosophila epithelia

Title
The moleskin gene product is essential for Caudal-mediated constitutive antifungal Drosomycin gene expression in Drosophila epithelia
Authors
Han S.-H.Ryu J.-H.Oh C.-T.Nam K.-B.Nam H.-J.Jang I.-H.Brey P.T.Lee W.-J.
Ewha Authors
이원재
Issue Date
2004
Journal Title
Insect Molecular Biology
ISSN
0962-1075JCR Link
Citation
Insect Molecular Biology vol. 13, no. 3, pp. 323 - 327
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
The homeobox gene, Caudal, encodes the DNA-binding nuclear transcription factor that plays a crucial role during development and innate immune response. The Drosophila homologue of importin-7 (DIM-7), encoded by moleskin, was identified as a Caudal-interacting molecule during yeast two-hybrid screening. Both mutation of the minimal region of Caudal responsible for moleskin binding and RNA interference (RNAi) of moleskin dramatically inhibited the Caudal nuclear localization. Furthermore, Caudal-mediated constitutive expression of antifungal Drosomycin gene was severely affected in the moleskin-RNAi flies, showing a local Drosomycin expression pattern indistinguishable from that of the Caudal-RNAi flies. These in vivo data suggest that DIM-7 mediates Caudal nuclear localization, which is important for the proper Caudal function necessary for regulating innate immune genes in Drosophila.
DOI
10.1111/j.0962-1075.2004.00491.x
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일반대학원 > 바이오융합과학과 > Journal papers
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