Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이원재 | - |
dc.date.accessioned | 2018-05-02T08:15:40Z | - |
dc.date.available | 2018-05-02T08:15:40Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0962-1075 | - |
dc.identifier.other | OAK-2178 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242764 | - |
dc.description.abstract | The homeobox gene, Caudal, encodes the DNA-binding nuclear transcription factor that plays a crucial role during development and innate immune response. The Drosophila homologue of importin-7 (DIM-7), encoded by moleskin, was identified as a Caudal-interacting molecule during yeast two-hybrid screening. Both mutation of the minimal region of Caudal responsible for moleskin binding and RNA interference (RNAi) of moleskin dramatically inhibited the Caudal nuclear localization. Furthermore, Caudal-mediated constitutive expression of antifungal Drosomycin gene was severely affected in the moleskin-RNAi flies, showing a local Drosomycin expression pattern indistinguishable from that of the Caudal-RNAi flies. These in vivo data suggest that DIM-7 mediates Caudal nuclear localization, which is important for the proper Caudal function necessary for regulating innate immune genes in Drosophila. | - |
dc.language | English | - |
dc.title | The moleskin gene product is essential for Caudal-mediated constitutive antifungal Drosomycin gene expression in Drosophila epithelia | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 13 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 323 | - |
dc.relation.lastpage | 327 | - |
dc.relation.journaltitle | Insect Molecular Biology | - |
dc.identifier.doi | 10.1111/j.0962-1075.2004.00491.x | - |
dc.identifier.wosid | WOS:000221544800012 | - |
dc.identifier.scopusid | 2-s2.0-2942708039 | - |
dc.author.google | Han S.-H. | - |
dc.author.google | Ryu J.-H. | - |
dc.author.google | Oh C.-T. | - |
dc.author.google | Nam K.-B. | - |
dc.author.google | Nam H.-J. | - |
dc.author.google | Jang I.-H. | - |
dc.author.google | Brey P.T. | - |
dc.author.google | Lee W.-J. | - |
dc.contributor.scopusid | 이원재(57171092600) | - |
dc.date.modifydate | 20211210153636 | - |