Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승록 | - |
dc.date.accessioned | 2018-05-02T08:15:38Z | - |
dc.date.available | 2018-05-02T08:15:38Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.other | OAK-2205 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242757 | - |
dc.description.abstract | Stimulation of cells with tumor necrosis factor-α (TNF-α) results in the increase in generation of H2O2 in mitochondria that leads to apoptosis. The effect of H2O2 produced by TNF-α on the redox status of selenocysteine (SeCys) residue essential for mitochondrial thioredoxin reductase (TrxR2) was investigated in HeLa cells. TNF-α caused accumulation of oxidized TrxR2 with a thioselenide bond. The conditional induction of SeCys-deficient TrxR2 resulted in the increased production of H2O2 and apoptosis. These results suggest that the SeCys residue of TrxR2 plays a critical role in cell survival by serving as an electron donor for Trx-II and subsequent peroxiredoxin-III, which is a primary line of defense against H 2O2 in mitochondria. © 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.title | Oxidation of thioredoxin reductase in HeLa cells stimulated with tumor necrosis factor-α | - |
dc.type | Article | - |
dc.relation.issue | 41308 | - |
dc.relation.volume | 567 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 189 | - |
dc.relation.lastpage | 196 | - |
dc.relation.journaltitle | FEBS Letters | - |
dc.identifier.doi | 10.1016/j.febslet.2004.04.055 | - |
dc.identifier.wosid | WOS:000221890000007 | - |
dc.identifier.scopusid | 2-s2.0-2942565661 | - |
dc.author.google | Kim J.-R. | - |
dc.author.google | Lee S.-M. | - |
dc.author.google | Cho S.-H. | - |
dc.author.google | Kim J.-H. | - |
dc.author.google | Kim B.-H. | - |
dc.author.google | Kwon J. | - |
dc.author.google | Choi C.Y. | - |
dc.author.google | Kim Y.-D. | - |
dc.author.google | Lee S.-R. | - |
dc.contributor.scopusid | 이승록(7409773214) | - |
dc.date.modifydate | 20211210152212 | - |