Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤여준 | - |
dc.date.accessioned | 2018-05-02T08:15:27Z | - |
dc.date.available | 2018-05-02T08:15:27Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0378-1097 | - |
dc.identifier.other | OAK-2349 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242697 | - |
dc.description.abstract | A mutant strain of Streptomyces venezuelae was engineered by deletion of the entire gene cluster related to biosynthesis of the endogenous deoxysugar (TDP-d-desosamine) and replacement with genes required for biosynthesis of an intermediate sugar (TDP-4-keto-6-deoxy-d-glucose) or an exogenous sugar (TDP-d-olivose), from the oleandomycin and urdamycin deoxysugar pathways. The 'sugar-flexible' glycosyltransferase (DesVII) was able to attach the intermediate sugar and the new sugar to both 12- and 14-membered macrolactones thus producing quinovose or olivose glycosylated 10-deoxymethynolide and narbonolide, respectively. In addition, hydroxylated analogs of the new metabolites were detected. These results demonstrate a successful attempt of engineering the deoxysugar pathway for generation of novel hybrid macrolide antibiotics. © 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.title | New olivosyl derivatives of methymycin/pikromycin from an engineered strain of Streptomyces venezuelae | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 238 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 391 | - |
dc.relation.lastpage | 399 | - |
dc.relation.journaltitle | FEMS Microbiology Letters | - |
dc.identifier.doi | 10.1016/j.femsle.2004.08.002 | - |
dc.identifier.wosid | WOS:000223926400015 | - |
dc.identifier.scopusid | 2-s2.0-4444246615 | - |
dc.author.google | Hong J.S.J. | - |
dc.author.google | Park S.H. | - |
dc.author.google | Choi C.Y. | - |
dc.author.google | Sohng J.K. | - |
dc.author.google | Yoon Y.J. | - |
dc.contributor.scopusid | 윤여준(7402126465) | - |
dc.date.modifydate | 20210708161345 | - |