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Oxidizing intermediates in cytochrome P450 model reactions

Title
Oxidizing intermediates in cytochrome P450 model reactions
Authors
Nam W.Ryu Y.O.Song W.J.
Ewha Authors
남원우
SCOPUS Author ID
남원우scopus
Issue Date
2004
Journal Title
Journal of Biological Inorganic Chemistry
ISSN
0949-8257JCR Link
Citation
Journal of Biological Inorganic Chemistry vol. 9, no. 6, pp. 654 - 660
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Oxoiron(IV) porphyrin π-cation radicals have been considered as the sole reactive species in the catalytic oxidation of organic substrates by cytochromes P450 and their iron porphyrin models over the past two decades. Recent studies from several laboratories, however, have provided experimental evidence that multiple oxidizing species are involved in the oxygen transfer reactions and that the mechanism of oxygen transfer is much more complex than initially believed. In this Commentary, reactive intermediates that have been shown or proposed to be involved in iron porphyrin complex-catalyzed oxidation reactions are reviewed. Particularly, the current controversy on the oxoiron(IV) porphyrin π-cation radical as a sole reactive species versus the involvement of multiple oxidizing species in oxygen transfer reactions is discussed.
DOI
10.1007/s00775-004-0577-5
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자연과학대학 > 화학·나노과학전공 > Journal papers
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