Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정낙신 | - |
dc.date.accessioned | 2018-05-02T08:15:26Z | - |
dc.date.available | 2018-05-02T08:15:26Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.other | OAK-2356 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242692 | - |
dc.description.abstract | Novel 3′-ureidoadenosine analogues, 3 and 4 were synthesized from 1,2:5,6-di-O-isopropylidene-d-glucose in order to cause stronger hydrogen bonding than the corresponding 3′-aminoadenosine derivatives at the A 3 adenosine receptor. On the basis of high binding affinity at the A 3 adenosine receptor of 3′-aminoadenosine derivatives with hydrogen bonding donor ability, novel 3′-ureidoadenosine analogues were synthesized from 1,2:5,6-di-O-isopropylidene-d-glucose in order to lead to stronger hydrogen bonding than the corresponding 3′-aminoadenosine derivatives. However, the synthesized 3′-ureidoadenosine analogues were totally devoid of binding affinity, because 3′-urea moiety caused steric and electrostatic repulsions at the binding site of the A 3 adenosine receptor, leading to conformational distortion. © 2004 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Design and synthesis of 3′-ureidoadenosine-5′-uronamides: Effects of the 3′-ureido group on binding to the A 3 adenosine receptor | - |
dc.type | Article | - |
dc.relation.issue | 19 | - |
dc.relation.volume | 14 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 4851 | - |
dc.relation.lastpage | 4854 | - |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry Letters | - |
dc.identifier.doi | 10.1016/j.bmcl.2004.07.042 | - |
dc.identifier.wosid | WOS:000224013000009 | - |
dc.identifier.scopusid | 2-s2.0-4444254918 | - |
dc.author.google | Jeong L.S. | - |
dc.author.google | Kim M.J. | - |
dc.author.google | Kim H.O. | - |
dc.author.google | Gao Z.-G. | - |
dc.author.google | Kim S.-K. | - |
dc.author.google | Jacobson K.A. | - |
dc.author.google | Chun M.W. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.date.modifydate | 20211210153610 | - |