Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오구택 | * |
dc.date.accessioned | 2018-05-02T08:15:24Z | - |
dc.date.available | 2018-05-02T08:15:24Z | - |
dc.date.issued | 2004 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-2374 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242683 | - |
dc.description.abstract | Genes induced or suppressed by oxidized low-density lipoproteins (oxLDL) in human monocytic THP-1 cells were searched using the differential display reverse transcriptase polymerase chain reaction. One of the differentially expressed (up-regulated) cDNA fragments was found to contain sequences corresponding to monocyte chemotactic protein-3 (MCP-3). The stimulatory effect of the oxLDL on the expression of MCP-3 mRNA was both time- and dose-dependent. Treatment with GF109203X and genistein, inhibitors of protein kinase C and tyrosine kinase, respectively, had no effect on the induction of MCP-3 mRNA by oxLDL, while treatment with cycloheximide inhibited the induction. The induction was reproduced by the lipid components in oxLDL such as 9-HODE and 13-HODE, which are known to activate the peroxisome proliferator-activated receptor γ (PPARγ). Introduction of an endogenous PPARγ ligand, 15d-PGJ2, in the culture of THP-1 cells resulted in the induction of MCP-3 gene expression. Furthermore, analyses of human atherosclerotic plaques revealed that the expressional pattern of MCP-3 in the regions of neointimal and necrotic core overlapped with that of PPARγ. These results suggest that oxLDL delivers its signal for MCP-3 expression via PPARγ, which may be further related to the atherogenesis. © 2004 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | Oxidized low-density lipoproteins may induce expression of monocyte chemotactic protein-3 in atherosclerotic plaques | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 323 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 898 | * |
dc.relation.lastpage | 905 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/j.bbrc.2004.08.178 | * |
dc.identifier.wosid | WOS:000224232100027 | * |
dc.identifier.scopusid | 2-s2.0-4544264626 | * |
dc.author.google | Jang M.K. | * |
dc.author.google | Kim J.Y. | * |
dc.author.google | Jeoung N.H. | * |
dc.author.google | Kang M.A. | * |
dc.author.google | Choi M.-S. | * |
dc.author.google | Oh G.T. | * |
dc.author.google | Nam K.T. | * |
dc.author.google | Lee W.-H. | * |
dc.author.google | Park Y.B. | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.date.modifydate | 20240123094756 | * |