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Metabolic phenotyping of human atherosclerotic plaques: Metabolic alterations and their biological relevance in plaque-containing aorta
- Title
- Metabolic phenotyping of human atherosclerotic plaques: Metabolic alterations and their biological relevance in plaque-containing aorta
- Authors
- Jung, Sunhee; Song, Suk-Won; Lee, Sak; Kim, Se Hoon; Ann, Soo-jin; Cheon, Eun Jeong; Yi, Gijong; Choi, Eui-Young; Lee, Seung Hyun; Joo, Hyun-Chel; Ryu, Do Hyun; Lee, Sang-Hak; Hwang, Geum-Sook
- Ewha Authors
- 황금숙
- SCOPUS Author ID
- 황금숙
- Issue Date
- 2018
- Journal Title
- ATHEROSCLEROSIS
- ISSN
- 0021-9150
1879-1484
- Citation
- ATHEROSCLEROSIS vol. 269, pp. 21 - 28
- Keywords
- Atherosclerosis; Metabolomics; Lipidomics; Quinic acid
- Publisher
- ELSEVIER IRELAND LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background and aims: Atherosclerosis is a chronic inflammatory disease characterized by thickening of the arterial wall. However, a limited number of studies have been conducted on metabolic profiling of human aortic tissue. Methods: We applied liquid chromatography/mass spectrometry to perform global and targeted profiling of plaque-containing aortic tissue. The aorta samples included plaque-containing (n = 18) and control plaque-free (n = 24) aortic tissue from patients undergoing aortic surgery. Results: The metabolic patterns of atherosclerotic and control vessels were significantly different. Meta-bolites in the purine and glutathione pathways showed dysregulation of oxidative stress in plaques, and levels of glucosylceramide, tryptophan, and kynurenine, which are related to inflammation, were also altered. Interestingly, an increased level of quinic acid was observed in plaques (p < 0.000), and we demonstrated an inhibitory effect of quinic acid on inflammatory activation and oxidative stress in macrophages. Conclusions: Our study provides insight into the disease mechanism and potential markers of atherosclerosis through comprehensive metabolic profiling of human aortic tissue samples containing plaque. (c) 2017 Elsevier B.V. All rights reserved.
- DOI
- 10.1016/j.atherosclerosis.2017.11.034
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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