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Cytoprotective dihydronaphthalenones from the wood of Catalpa ovata

Title
Cytoprotective dihydronaphthalenones from the wood of Catalpa ovata
Authors
Kil, Yun-SeoSo, Yang KangChoi, Min JungHan, Ah-ReumJin, Chang HyunSeo, Eun Kyoung
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2018
Journal Title
PHYTOCHEMISTRY
ISSN
0031-9422JCR Link
Citation
PHYTOCHEMISTRY vol. 147, pp. 14 - 20
Keywords
Catalpa ovataBignoniaceaeDihydronaphthalenonePhthalideCytoprotective effectsReactive oxygen speciesHeme oxygenase-1NAD(P)H:quinine oxidoreductase 1
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Three previously undescribed dihydronaphthalenones, 7-hydroxycatalponol, (4S)-3,4-dihydro-4-hydroxy-2-[(2R)-2,3-dihydroxy-3-methylbutylidene]naphthalen-1(2H)-one, and (6S)-5,6-dihydro-6-hydroxy-2,2-dimethyl-2H-benzo[h]chromen-4(3H)-one and one phthalide, (+/-)-3-(5-hydroxy-5-methyl-2-oxohex-3-en-1-yl)isobenzofuran-1(3H)-one, were isolated from the wood of Catalpa ovata G. Don (Bignoniaceae), together with six known compounds. The structures of the previously undescribed compounds were elucidated by interpretation of 1D and 2D NMR data. The absolute configurations of the dihydronaphthalenones were deduced by analysis of the ECD data and application of Mosher ester methodology. All isolates were investigated for their cytoprotective effects against hydrogen peroxide (H2O2)-induced oxidative damage in HepG2 cells. Moreover, the mRNA expression levels of antioxidant enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinine oxidoreductase 1 (NQO1) in HepG2 cells were examined by RT-PCR analysis. As a result, catalponol and epi-catalponol showed antioxidant activities via directly scavenging of intracellular ROS and inducing the antioxidant enzymes in vitro. (C) 2017 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.phytochem.2017.12.009
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약학대학 > 약학과 > Journal papers
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