Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이공주 | - |
dc.date.accessioned | 2018-04-25T08:13:38Z | - |
dc.date.available | 2018-04-25T08:13:38Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.other | OAK-21901 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242562 | - |
dc.description.abstract | Ubiquitin C-terminal hydrolase-L1 (UCH-L1), which catalyzes the hydrolysis of ubiquitin esters and amides, is highly expressed in brain. Recently, UCH-L1 has been found to increase cancer cell migration and invasion by modulating hydrogen peroxide generated by NADPH oxidase 4 (NOX4). Because angiogenesis is also mediated by hydrogen peroxide, we explored the role of UCH-L1 in angiogenesis in human umbilical vein endothelial cells (HUVECs). Silencing UCH-L1 suppressed tubule formation in HUVECs, indicating that UCH-L1 promotes angiogenesis in vitro. This was confirmed using in vivo Matrigel plug studies of HUVECs, after overexpressing or silencing UCH-L1. Silencing UCH-L1 significantly suppressed VEGF-induced ROS levels as well as activation of VEGFR, both of which are required for angiogenesis. This study also showed that UCH-L1 promotes angiogenesis of HUVECs, as well as invasion in cancer cells, by up-regulating ROS by deubiquitination of NOX4, suggesting that UCH-L1 plays a key role in angiogenesis of HUVECS by regulating ROS levels by deubiquitination of NOX4. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | UCH-L1 | - |
dc.subject | Angiogenesis | - |
dc.subject | Endothelial cells | - |
dc.subject | NADPH oxidase 4 | - |
dc.subject | Deubiquitination | - |
dc.subject | Hydrogen peroxide | - |
dc.title | Ubiquitin C-terminal hydrolase-L1 plays a key role in angiogenesis by regulating hydrogen peroxide generated by NADPH oxidase 4 | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 495 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1567 | - |
dc.relation.lastpage | 1572 | - |
dc.relation.journaltitle | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2017.11.051 | - |
dc.identifier.wosid | WOS:000423897600234 | - |
dc.identifier.scopusid | 2-s2.0-85038866333 | - |
dc.author.google | Song, In-Kang | - |
dc.author.google | Kim, Hyun Jung | - |
dc.author.google | Magesh, Venkataraman | - |
dc.author.google | Lee, Kong-Joo | - |
dc.contributor.scopusid | 이공주(7501497635;57191532162) | - |
dc.date.modifydate | 20230208115507 | - |