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자연과학대학
화학·나노과학전공
Journal papers
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Biosynthetic pathways of aminoglycosides and their engineering
Title
Biosynthetic pathways of aminoglycosides and their engineering
Authors
Park J.W.
;
Ban Y.H.
;
Nam S.-J.
;
Cha S.-S.
;
Yoon Y.J.
Ewha Authors
윤여준
;
남상집
;
차선신
;
반연희
SCOPUS Author ID
윤여준
; 남상집
; 차선신
; 반연희
Issue Date
2017
Journal Title
Current Opinion in Biotechnology
ISSN
0958-1669
Citation
Current Opinion in Biotechnology vol. 48, pp. 33 - 41
Publisher
Elsevier Ltd
Indexed
SCIE; SCOPUS
Document Type
Review
Abstract
Despite decades long clinical usage, aminoglycosides still remain a valuable pharmaceutical source for fighting Gram-negative bacterial pathogens, and their newly identified bioactivities are also renewing interest in this old class of antibiotics. As Nature's gift, some aminoglycosides possess natural defensive structural elements that can circumvent drug resistance mechanisms. Thus, a detailed understanding of aminoglycoside biosynthesis will enable us to apply Nature's biosynthetic strategy towards expanding structural diversity in order to produce novel and more robust aminoglycoside analogs. The engineered biosynthesis of novel aminoglycosides is required not only to develop effective therapeutics against the emerging ‘superbugs’ but also to reinvigorate antibiotic lead discovery in readiness for the emerging post-antibiotic era. © 2017 Elsevier Ltd
DOI
10.1016/j.copbio.2017.03.019
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