View : 9 Download: 0

Biosynthetic pathways of aminoglycosides and their engineering

Title
Biosynthetic pathways of aminoglycosides and their engineering
Authors
Park J.W.Ban Y.H.Nam S.-J.Cha S.-S.Yoon Y.J.
Ewha Authors
윤여준남상집차선신
SCOPUS Author ID
윤여준scopus; 남상집scopus; 차선신scopus
Issue Date
2017
Journal Title
Current Opinion in Biotechnology
ISSN
0958-1669JCR Link
Citation
vol. 48, pp. 33 - 41
Publisher
Elsevier Ltd
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Despite decades long clinical usage, aminoglycosides still remain a valuable pharmaceutical source for fighting Gram-negative bacterial pathogens, and their newly identified bioactivities are also renewing interest in this old class of antibiotics. As Nature's gift, some aminoglycosides possess natural defensive structural elements that can circumvent drug resistance mechanisms. Thus, a detailed understanding of aminoglycoside biosynthesis will enable us to apply Nature's biosynthetic strategy towards expanding structural diversity in order to produce novel and more robust aminoglycoside analogs. The engineered biosynthesis of novel aminoglycosides is required not only to develop effective therapeutics against the emerging ‘superbugs’ but also to reinvigorate antibiotic lead discovery in readiness for the emerging post-antibiotic era. © 2017 Elsevier Ltd
DOI
10.1016/j.copbio.2017.03.019
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE