View : 2 Download: 0

The therapeutic effects of Yongdamsagan-tang on autoimmune hepatitis models

Title
The therapeutic effects of Yongdamsagan-tang on autoimmune hepatitis models
Authors
Park, JiyoungKim, HayeonLee, In-SeungKim, Kang-HoonKim, YumiNa, Yun-CheolLee, Jang-HoonJang, Hyeung-Jin
Ewha Authors
나윤철
Issue Date
2017
Journal Title
BIOMEDICINE & PHARMACOTHERAPY
ISSN
0753-3322JCR Link1950-6007JCR Link
Citation
vol. 94, pp. 244 - 255
Keywords
Anti-inflammationAnti-fibrosisAnti-steatosisRecombinant IL-17AAutoimmune hepatitis cell modelConcanavalin AYongdamsagan-tangAutoimmune hepatitisAIH
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Autoimmune hepatitis (AIH) is an immunity disorder that is the result of antibodies in the liver tissue of the patient that are attacked by activated immune cells due to an unknown cause. In this study, we aimed to investigate the anti-inflammatory effect of Yongdamsagan-tang (YST) extracts and confirm effects on autoimmune hepatitis models as the therapeutic agent using the YST extracted by various solvents. YST, a mixture of 11 herbal extracts, is known in traditional Korean medicine as a widely used treatment for inflammatory diseases. We proposed the AIH-condition in vitro model by the addition of recombinant IL-17A and then observed several markers linked to AIH symptoms, including an increase of IL-6 expression, lipid accumulation, and fibrosis. In AIH-condition hepatic cell model, YST reduced IL-6 expression and lipid accumulation caused by treatment of IL-17 combination in hepatocyte cells. Also, YST blocked several activated fibrosis factors including transforming growth factor-beta (TGF-beta 1), collagen type 1 (Col-alpha 1(I)), and alpha-smooth muscle actin (alpha-SMA) in liver stellate cells. Furthermore, pretreatment with YST protected hepatic damage and reduces histological injury by suppressing apoptosis mediator and inflammatory cytokines expression in concanavalin A (Con A)-induced autoimmune hepatitis mice model. The findings here improve our understanding of YST extracted by 80% ethanol, suggesting that YST can be used as a therapeutic treatment for AIH. (C) 2017 Elsevier Masson SAS. All rights reserved.
DOI
10.1016/j.biopha.2017.07.015
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE