Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2018-01-11T16:30:33Z | - |
dc.date.available | 2018-01-11T16:30:33Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 2161-1653 | * |
dc.identifier.other | OAK-21629 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239686 | - |
dc.description.abstract | To investigate the effect of receptor substrate of target cells on stem cell differentiation, lactobionic acid-conjugated poly-[(propylene glycol)-b-(ethylene glycol)-b-(propylene glycol)]-poly(L-alanine) (LB-PLX-PA) was synthesized, and then thermogelling systems consisting of LB-PLX-PA and PLX-PA in a ratio of 0/100 (LB-0), 5/95 (LB-5), and 20/80 (LB-20) were constructed as an injectable three-dimensional scaffold toward hepatogenic differentiation of tonsil-derived mesenchymal stem cells (TMSCs). Modulus of LB-0, LB-5, and LB-20 increased to 500-800 Pa at 37 degrees C (gel) due to the heat induced sol-to-gel transition of the systems during which TMSCs were incorporated into the gel. Based on biomarker expressions and hepatic biofunctions of the differentiated cells, the receptor substrate (LB)-conjugated bioactive thermogel provides compatible microenvironments for the differentiated cells, and thus gives pronounced positive results on the differentiation of the stem cells into target cells during three-dimensional culture, compared with a passive thermogel. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.title | Hepatogenic Supported Differentiation of Mesenchymal Stem Cells in a Lactobionic Acid-Conjugated Thermogel | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 6 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1305 | * |
dc.relation.lastpage | 1309 | * |
dc.relation.journaltitle | ACS MACRO LETTERS | * |
dc.identifier.doi | 10.1021/acsmacrolett.7b00802 | * |
dc.identifier.wosid | WOS:000416500000024 | * |
dc.identifier.scopusid | 2-s2.0-85034741010 | * |
dc.author.google | Moon, Hyo Jung | * |
dc.author.google | Lee, Hyun Jung | * |
dc.author.google | Patel, Madhumita | * |
dc.author.google | Park, Sohee | * |
dc.author.google | Chang, Seo Hee | * |
dc.author.google | Jeong, Byeongmoon | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |