View : 49 Download: 0

Disruption of Ninjurin1 Leads to Repetitive and Anxiety-Like Behaviors in Mice

Title
Disruption of Ninjurin1 Leads to Repetitive and Anxiety-Like Behaviors in Mice
Authors
Le H.Ahn B.J.Lee H.S.Shin A.Chae S.Lee S.Y.Shin M.W.Lee E.-J.Cha J.-H.Son T.Seo J.H.Wee H.-J.Lee H.-J.Jang Y.Lo E.H.Jeon S.Oh G.T.Kim D.Kim K.-W.
Ewha Authors
오구택
SCOPUS Author ID
오구택scopus
Issue Date
2017
Journal Title
Molecular Neurobiology
ISSN
0893-7648JCR Link
Citation
vol. 54, no. 9, pp. 7353 - 7368
Keywords
Anxiety-like behaviorFluoxetineGlutamate receptorsNinj1OCDRepetitive behavior
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Over the last few decades, molecular neurobiology has uncovered many genes whose deficiency in mice results in behavioral traits associated with human neuropsychiatric disorders such as autism, obsessive-compulsive disorder (OCD), and schizophrenia. However, the etiology of these common diseases remains enigmatic with the potential involvement of a battery of genes. Here, we report abnormal behavioral phenotypes of mice deficient in a cell adhesion molecule Ninjurin 1 (Ninj1), which are relevant to repetitive and anxiety behaviors of neuropsychiatric disorders. Ninj1 knockout (KO) mice exhibit compulsive grooming-induced hair loss and self-made lesions as well as increased anxiety-like behaviors. Histological analysis reveals that Ninj1 is predominantly expressed in cortico-thalamic circuits, and neuron-specific Ninj1 conditional KO mice manifest aberrant phenotypes similar to the global Ninj1 KO mice. Notably, the brains of Ninj1 KO mice display altered synaptic transmission in thalamic neurons as well as a reduced number of functional synapses. Moreover, the disruption of Ninj1 leads to glutamatergic abnormalities, including increased ionotropic glutamate receptors but reduced glutamate levels. Furthermore, chronic treatment with fluoxetine, a drug reportedly ameliorates compulsive behaviors in mice, prevents progression of hair loss and alleviates the compulsive grooming and anxiety-like behavior of Ninj1 KO mice. Collectively, our results suggest that Ninj1 could be involved in neuropsychiatric disorders associated with impairments of repetitive and anxiety behaviors. © 2016, Springer Science+Business Media New York.
DOI
10.1007/s12035-016-0207-6
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE