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Insertable NO/CO Microsensors Recording Gaseous Vasomodulators Reflecting Differential Neuronal Activation Level with Respect to Seizure Focus

Title
Insertable NO/CO Microsensors Recording Gaseous Vasomodulators Reflecting Differential Neuronal Activation Level with Respect to Seizure Focus
Authors
Ha Y.Lee Y.Suh M.
Ewha Authors
이영미
SCOPUS Author ID
이영미scopus
Issue Date
2017
Journal Title
ACS Chemical Neuroscience
ISSN
1948-7193JCR Link
Citation
vol. 8, no. 9, pp. 1853 - 1858
Keywords
amperometric sensorcarbon monoxideepileptic seizurelocal field potentialNitric oxide
Publisher
American Chemical Society
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Nitric oxide (NO) and carbon monoxide (CO) are important signaling molecules shaping vasomodulation. This paper reports simultaneous in vivo monitoring of NO, CO and dendritic summation of action potential at three different cortical regions: seizure focus and two additional places, vertically and horizontally separated by 1.2 mm from the seizure focus, during epileptic seizure induced by 4-aminopyrindine injection. An amperometric dual microsensor having a high spatiotemporal resolution monitored fast and dynamic changes of NO and CO, and neural changes were recorded with a glass pipet electrode for local field potential (LFP). At all three locations, onsets and offsets of NO and CO changes well synchronized with fast LFP changes, while the patterns and concentrations of NO and CO changes were varied depending on the sensing locations. The insertable NO/CO dual microsensor was successful to measure intimately linked NO and CO in acute seizure events with high sensitivity, selectivity, and spatiotemporal resolution. © 2017 American Chemical Society.
DOI
10.1021/acschemneuro.7b00141
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자연과학대학 > 화학·나노과학전공 > Journal papers
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