Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤여준 | * |
dc.contributor.author | 차선신 | * |
dc.date.accessioned | 2017-12-27T16:31:13Z | - |
dc.date.available | 2017-12-27T16:31:13Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 2041-1723 | * |
dc.identifier.other | OAK-21371 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239441 | - |
dc.description.abstract | The chaperonins (CPNs) are megadalton sized hollow complexes with two cavities that open and close to encapsulate non-native proteins. CPNs are assigned to two sequence-related groups that have distinct allosteric mechanisms. In Group I CPNs a detachable co-chaperone, GroES, closes the chambers whereas in Group II a built-in lid closes the chambers. Group I CPNs have a bacterial ancestry, whereas Group II CPNs are archaeal in origin. Here we describe open and closed crystal structures representing a new phylogenetic branch of CPNs. These Group III CPNs are divergent in sequence and structure from extant CPNs, but are closed by a built-in lid like Group II CPNs. A nucleotide-sensing loop, present in both Group I and Group II CPNs, is notably absent. We identified inter-ring pivot joints that articulate during ring closure. These Group III CPNs likely represent a relic from the ancestral CPN that formed distinct bacterial and archaeal branches. © 2017 The Author(s). | * |
dc.language | English | * |
dc.publisher | Nature Publishing Group | * |
dc.title | Structural and mechanistic characterization of an archaeal-like chaperonin from a thermophilic bacterium | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 8 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Nature Communications | * |
dc.identifier.doi | 10.1038/s41467-017-00980-z | * |
dc.identifier.wosid | WOS:000412603600012 | * |
dc.identifier.scopusid | 2-s2.0-85031018484 | * |
dc.author.google | An Y.J. | * |
dc.author.google | Rowland S.E. | * |
dc.author.google | Na J.-H. | * |
dc.author.google | Spigolon D. | * |
dc.author.google | Hong S.K. | * |
dc.author.google | Yoon Y.J. | * |
dc.author.google | Lee J.-H. | * |
dc.author.google | Robb F.T. | * |
dc.author.google | Cha S.-S. | * |
dc.contributor.scopusid | 윤여준(7402126465) | * |
dc.contributor.scopusid | 차선신(7201864593) | * |
dc.date.modifydate | 20240429134916 | * |