Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장준 | * |
dc.date.accessioned | 2017-11-01T05:02:01Z | - |
dc.date.available | 2017-11-01T05:02:01Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 2211-1247 | * |
dc.identifier.other | OAK-21295 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239083 | - |
dc.description.abstract | MicroRNA (miR)-150 is a developmental regulator of several immune-cell types, but its role in CD8+ T cells is largely unexplored. Here, we show that miR-150 regulates the generation of memory CD8+ T cells. After acute virus infection, miR-150 knockout (KO) mice exhibited an accelerated differentiation of CD8+ T cells into memory cells and improved production of effector cytokines. Additionally, miR-150 KO CD8+ T cells displayed an enhanced recall response and improved protection against infections with another virus and bacteria. We found that forkhead box O1 (Foxo1) and T cell-specific transcription factor 1 (TCF1) are upregulated during the early activation phase in miR-150 KO CD8+ T cells and that miR-150 directly targets and suppresses Foxo1. These results suggest that miR-150-mediated suppression of Foxo1 regulates the balance between effector and memory cell differentiation, which might aid in the development of improved vaccines and T cell therapeutics. © 2017 The Authors | * |
dc.description.sponsorship | Elsevier B.V. | * |
dc.language | English | * |
dc.subject | acute | * |
dc.subject | CD8 | * |
dc.subject | differentiation | * |
dc.subject | Foxo1 | * |
dc.subject | infection | * |
dc.subject | LCMV | * |
dc.subject | memory | * |
dc.subject | miR-150 | * |
dc.subject | primary immune response | * |
dc.subject | recall | * |
dc.title | miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 20 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2598 | * |
dc.relation.lastpage | 2611 | * |
dc.relation.journaltitle | Cell Reports | * |
dc.identifier.doi | 10.1016/j.celrep.2017.08.065 | * |
dc.identifier.wosid | WOS:000410377400008 | * |
dc.identifier.scopusid | 2-s2.0-85029386642 | * |
dc.author.google | Ban Y.H. | * |
dc.author.google | Oh S.-C. | * |
dc.author.google | Seo S.-H. | * |
dc.author.google | Kim S.-M. | * |
dc.author.google | Choi I.-P. | * |
dc.author.google | Greenberg P.D. | * |
dc.author.google | Chang J. | * |
dc.author.google | Kim T.-D. | * |
dc.author.google | Ha S.-J. | * |
dc.contributor.scopusid | 장준(8735999100) | * |
dc.date.modifydate | 20231120165756 | * |