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Enhanced accumulation of theranostic nanoparticles in brain tumor by external magnetic field mediated in situ clustering of magnetic nanoparticles

Title
Enhanced accumulation of theranostic nanoparticles in brain tumor by external magnetic field mediated in situ clustering of magnetic nanoparticles
Authors
Lee K.David A.E.Zhang J.Shin M.C.Yang V.C.
Ewha Authors
이규리
Issue Date
2017
Journal Title
Journal of Industrial and Engineering Chemistry
ISSN
1226-086XJCR Link
Citation
vol. 54, pp. 389 - 397
Keywords
Brain tumorin situ formationMagnetic iron oxide nanoparticles (MIONs)Magnetically guided drug delivery
Publisher
Korean Society of Industrial Engineering Chemistry
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Magnetic iron oxide nanoparticles (MIONs) have received much attention due to their unique properties such as ferromagnetic and superparamagnetic characters. These magnetic properties enable the broad use of MIONs in biomedical applications including magnetic resonance imaging (MRI), magnetically guided delivery, and hyperthermal therapy. In particular, magnetic field guided delivery systems have shown promising potential in the development of targeted drug delivery systems for brain tumors. This system facilitates the extravasation and accumulation of MIONs within the brain tumor under external magnetic field. However, the practical use of MIONs is highly limited due to the large physical size of MIONs required for the sufficient retention and accumulation of particles in the brain tumor. This study aims to enhance the accumulation and retention of MIONs in the brain tumor by in situ formation of large clusters of MIONs. To achieve this goal, MIONs with core size of 100 nm were modified with free thiol end groups by conjugating bi-functional poly(ethylene glycol) (NHS-PEG-SH). It is expected that the prepared MIONs-PEG-SH remain stable during the systemic circulation. When the circulating MIONs-PEG-SH are exposed to the external magnetic field applied to the brain tumor, the local concentration of MIONs-PEG-SH can be increased and subsequent interactions among MIONs induce a disulfide bond formation. As a result, in situ formation of the large clusters of MIONs allows enhanced accumulation and retention of MIONs in a rat brain tumor model. Moreover, when doxorubicin is loaded onto the MIONs, the biodistribution of doxorubicin at brain tumor site is highly enhanced, suggesting their potential use in theranostic applications. © 2017 The Korean Society of Industrial and Engineering Chemistry
DOI
10.1016/j.jiec.2017.06.019
Appears in Collections:
약학대학 > 약학과 > Journal papers
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