Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이혁진 | * |
dc.date.accessioned | 2017-10-27T11:45:31Z | - |
dc.date.available | 2017-10-27T11:45:31Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0927-7765 | * |
dc.identifier.other | OAK-20944 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/237226 | - |
dc.description.abstract | Deoxyribonucleic acid (DNA) is a versatile material with high applicability and inherent biocompatibility. L-DNA, the perfect mirror form of the naturally occurring D-DNA, has been used in DNA nanotechnology. It has thermodynamically identical properties to D-DNA, is capable of self-assembly and bio-orthogonal base-pairing, and is resistant to nuclease activity. We previously constructed an L-DNA tetrahedron (L-Td) and found that this nanostructure has remarkably higher capacity for cell penetration than its natural counterpart (D-Td). L-Td molecules of two different sizes—one with 17-mer per side (L-Td17) and the other with 30-mer per side (L-Td30)—were prepared by assembling four L-DNA strands. In this study, cellular uptake of L-Td with different sizes was observed over time using a laser scanning confocal microscope (LSCM) equipped with a live cell chamber system. In addition, we conducted a pharmacokinetic study to examine the potential of L-Td as a carrier for in vivo tumor-targeted delivery of a low dose of doxorubicin (DOX). L-Td entered into the cells through endocytosis, and a specific DNA sequence of the L-Td ensures targeted entry into cancer cells. Compared with free DOX, DOX-loaded L-Td (DOX@L-Td) showed decreased clearance and increased initial concentration (C0), half-life, and area under the curve (AUC), indicating that DOX@L-Td circulated in the blood stream for longer than free DOX. L-Td17, in particular, had beneficial effects owing to its ability to enhance tumor accumulation of DOX and reduce the cardiotoxicity caused by it through administration of a low dose of the drug. © 2017 Elsevier B.V. | * |
dc.language | English | * |
dc.publisher | Elsevier B.V. | * |
dc.subject | DNA nanostructure | * |
dc.subject | DNA tetrahedron | * |
dc.subject | Doxorubicin | * |
dc.subject | Live cell imaging | * |
dc.subject | Tumor-targeted delivery | * |
dc.title | In vitro and in vivo behavior of DNA tetrahedrons as tumor-targeting nanocarriers for doxorubicin delivery | * |
dc.type | Article | * |
dc.relation.volume | 157 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 424 | * |
dc.relation.lastpage | 431 | * |
dc.relation.journaltitle | Colloids and Surfaces B: Biointerfaces | * |
dc.identifier.doi | 10.1016/j.colsurfb.2017.06.014 | * |
dc.identifier.wosid | WOS:000408597900049 | * |
dc.identifier.scopusid | 2-s2.0-85020917070 | * |
dc.author.google | Kang J.H. | * |
dc.author.google | Kim K.-R. | * |
dc.author.google | Lee H. | * |
dc.author.google | Ahn D.-R. | * |
dc.author.google | Ko Y.T. | * |
dc.contributor.scopusid | 이혁진(55233457200) | * |
dc.date.modifydate | 20240220111730 | * |