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The BDNF val66met polymorphism affects the vulnerability of the brain structural network

Title
The BDNF val66met polymorphism affects the vulnerability of the brain structural network
Authors
Park C.-H.Kim J.Namgung E.Lee D.-W.Kim G.H.Kim M.Kim N.Kim T.D.Kim S.Lyoo I.K.Yoon S.
Ewha Authors
류인균윤수정
SCOPUS Author ID
류인균scopus; 윤수정scopus
Issue Date
2017
Journal Title
Frontiers in Human Neuroscience
ISSN
1662-5161JCR Link
Citation
vol. 11
Keywords
BDNF Val66MetDiffusion tensor imagingNetwork resilienceTractographyWhite matter structural network
Publisher
Frontiers Media S. A
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Val66Met, a naturally occurring polymorphism in the human brain-derived neurotrophic factor (BDNF) gene resulting in a valine (Val) to methionine (Met) substitution at codon 66, plays an important role in neuroplasticity. While the effect of the BDNF Val66Met polymorphism on local brain structures has previously been examined, its impact on the configuration of the graph-based white matter structural networks is yet to be investigated. In the current study, we assessed the effect of the BDNF polymorphism on the network properties and robustness of the graph-based white matter structural networks. Graph theory was employed to investigate the structural connectivity derived from white matter tractography in two groups, Val homozygotes (n = 18) and Met-allele carriers (n = 55). Although there were no differences in the global network measures including global efficiency, local efficiency, and modularity between the two genotype groups, we found the effect of the BDNF Val66Met polymorphism on the robustness properties of the white matter structural networks. Specifically, the white matter structural networks of the Met-allele carrier group showed higher vulnerability to targeted removal of central nodes as compared with those of the Val homozygote group. These findings suggest that the central role of the BDNF Val66Met polymorphism in regards to neuroplasticity may be associated with inherent differences in the robustness of the white matter structural network according to the genetic variants. Furthermore, greater susceptibility to brain disorders in Met-allele carriers may be understood as being due to their limited stability in white matter structural connectivity. © 2017 Park, Kim, Namgung, Lee, Kim, Kim, Kim, Kim, Kim, Lyoo and Yoon.
DOI
10.3389/fnhum.2017.00400
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약학대학 > 약학과 > Journal papers
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