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Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127

Title
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127
Authors
Hwang J.S.Kim G.J.Choi H.G.Kim M.C.Hahn D.Nam J.-W.Nam S.-J.Kwon H.C.Chin J.Cho S.J.Hwang H.Choi H.
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2017
Journal Title
Journal of Natural Products
ISSN
0163-3864JCR Link
Citation
vol. 80, no. 8, pp. 2269 - 2275
Publisher
American Chemical Society
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Angiogenesis is the process of new blood vessel formation. Excessive angiogenesis is a critical factor in the progression of cancer, macular degeneration, and other chronic inflammatory diseases. When investigating the effects of crude extracts of cultured marine microorganisms, an extract of the cultured Streptomyces sp. YP127 strain was found to inhibit human umbilical vein endothelial cell (HUVEC) tube formation. Bioassay-guided fractionation and spectroscopic data analyses led to the identification of napyradiomycin A1 (1) as an antiangiogenic component of the extract. Compound 1 inhibited HUVEC tube formation in a concentration-dependent manner. It inhibited endothelial cell proliferation but did not affect human dermal fibroblast proliferation. Compound 1 also suppressed migration and invasion of vascular endothelial cells. In addition, compound 1 suppressed vascular endothelial cadherin expression and increased the permeability of the endothelial cell membrane. These results suggested that compound 1 modulates cell permeability and inhibits the angiogenesis of endothelial cells. © 2017 The American Chemical Society and American Society of Pharmacognosy.
DOI
10.1021/acs.jnatprod.7b00211
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자연과학대학 > 화학·나노과학전공 > Journal papers
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