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Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata

Title
Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata
Authors
Kil Y.-S.Kim S.M.Kang U.Chung H.Y.Seo E.K.
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2017
Journal Title
Journal of Natural Products
ISSN
0163-3864JCR Link
Citation
vol. 80, no. 8, pp. 2240 - 2251
Publisher
American Chemical Society
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Ten new glycosides, 6,10-O-di-trans-feruloyl catalpol (1), 6,6′-O-di-trans-feruloyl catalpol (2), 3,4-dihydro-6-O-di-trans-feruloyl catalpol (10), (8R,7′S,8′R)-lariciresinol 9′-O-β-d-(6-O-trans-feruloyl)glucopyranoside (17), and ovatosides A-F (18-22, 24), were isolated from the stem bark of Catalpa ovata along with 19 known compounds. All isolates, except 6 (catalposide) and 9 (6-O-veratroyl catalpol), were found to scavenge peroxynitrite (ONOO-) formed by 3-morpholinosydnonimine. In particular, 12 compounds showed potent activity, with IC50 values in the range 0.14-2.2 μM. © 2017 The American Chemical Society and American Society of Pharmacognosy.
DOI
10.1021/acs.jnatprod.7b00139
Appears in Collections:
약학대학 > 약학과 > Journal papers
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